The numbers is one of Lost's biggest mysteries. This page talks about the numbers, and their appearances in Lost and in the real world.

In Lost:

Season 1:

"Numbers"-

• Hurley's winning lottery numbers were the numbers.
• Danielle's notes had the numbers written on it 7 times.
• Leonard repeated the numbers over and over in the mental hospital; he heard them from Sam Toomey while they were in the Navy.

"Exodus: Part 2"-

• When Hurley's car broke down, the speedometer (kph) went down from 16 to 15 to 8 to 4, the odometer was at 42 km, and the temperature was 23C.
• Hurley went by a soccer team with the numbers on their back.
• The hatch of the Swan had the numbers on it.

Season 2:

"Man of Science, Man of Faith"-

• The vial Desmond inject himself with had the numbers on it.

"Adrift"-

• The numbers must be typed into the computer every 108 minutes.

"Maternity Leave"-

• The vial Ethan injected Claire with had the numbers on it.

"Lockdown"-

• The numbers appear on the blast door map.

Season 4:

"There's No Place Like Home: Part 1"-

• The mileage on Hurley's Camaro reads the numbers.

In Real Life:
The numbers do appear in real life in any mathematical equation, but there are a few close ones.

• In a lottery on 11/16/05 in Ireland, the numbers were 4 8 15 16 23 24.

• In the first 200,000,000 digits of the infinite equation of pi, the number 4815162343 appears.
• The numbers are all retired baseball jerseys for the Yankees.
• The coordinates latitude 4.815, longitude 162.342 is in the trail of a plane flying from Sydney to L.A. (see google maps here).